Milan can easily slip into the relegation zone if they fail to win this game, which should give the hosts enough motives to give their best.

Genoa hope new boss Luigi Del Neri will help the team end the four-match winless run or at least avoid defeat at San Siro.

Coach Max Allegri could face the chop unless the results improve soon, which is hardly surprising when we know this is club’s worst start to a league campaign in 60 years.

With 5 defeats in 8 Serie A games, the Rossoneri sit just above the relegation zone, meaning their third win of the campaign is long overdue.

Champions League defeat to Malaga, team’s third on the bounce, served as an additional blow to the players’ confidence, so you will forgive me for not jumping at the opportunity to bet on home win at odds of 1.57 (4/7) offered by Ladbrokes.

Christian Abbiatti and Nigel De Jong are both injury doubts, but Massimo Ambrosini returns after missing the Lazio defeat through suspension.

On the other hand, Sulley Muntari, Rodney Strasser, Didac Vila, Robinho and Djamel Mesbah remain long-term casualties.

Probable starting line-up (3-4-3): Abbiati – Mexes, Bonera, Yepes – Abate, Montolivo, Ambrosini, De Sciglio – Emanuelson, Pazzini, El Shaarawy.

Genoa have not had such a poor start to the season, so it is fair to say many were surprised by club’s decision to sack talented coach Luigi De Canio.

The Rossoblu, nonetheless, did well to bring experienced tactician Luigi Del Neri to replace him, with the former Atalanta boss returning into action more than a year after leaving Juventus in May 2011.

Therefore, Genoa, too, will have something to prove in this game, especially as they squandered a two-goal lead against Roma to record a 4-2 defeat.

Having recorded three straight draws prior to that match, the Rossoblu are now 4.00 (3/1) with BetVictor to bring one point from San Siro.

Top scorer Marco Borriello is set for a lengthy spell on the sidelines after picking up an ankle injury, while Michele Canini is suspended.

Brazilian Anselmo is doubtful, while Marco Rossi, Juan Manuel Vargas, Damiano Feronetti and Cristobal Jorquera are all out.

Probable starting line-up (4-4-1-1): Frey – Samprisi, Granqvist, Bovo, Moretti – Jankovic, Tozser, Kucka, Antonelli – Bertolacci – Immobile.