Inter will attempt to keep the slim European hopes alive by defeating AS Roma and at the same time avoid slipping into the bottom half of the standings.
The Giallorossi have seen their advantage over top 3 rivals Napoli melt to five points and another slip up could prove costly.
Everybody at Stadio Giuseppe Meazza will be eager to see the back of the current season so that they can start planning for the new campaign.
Despite failing to get the best out of his side, Roberto Mancini will probably be given a vote of confidence in the summer, but the playing squad will undergo major changes.
Inter still have an outside chance of clinching the final Europa League berth seeing as they sit seven points behind sixth-placed Fiorentina with seven games to go, but the Nerazzurri need to record several wins in a row in order to climb the league standings.
The 3-0 triumph over Hellas Verona and goalless draw in Derby della Madonnina can be seen as steps in the right direction, so bear in mind Roberto Mancini’s side are 2.40 (7/5) to see off AS Roma.
The coach will welcome back Fredy Guarin and Marcelo Brozovic from suspension, but now Gary Medel is banned for the Roma clash.
Davide Santon and Xherdan Shaqiri might have to settle for a place on the bench, whilst Zdravko Kuzmanovic, Hugo Campagnaro, Dodo and Jonathan are out injured.
Probable starting line-up (4-3-1-2): Handanovic – D’Ambrosio, Ranocchia, Vidic, Juan Jesus – Guarin, Kovacic, Brozovic – Hernanes – Icardi, Palacio.
This season is quickly turning into a major disappointment for AS Roma, who were effectively vying with Juventus for the league trophy and could now stay without Champions League qualification.
Nobody knows what exactly happened to Rudi Garcia’s team in the second part of the season, but the lack of confidence is clearly affecting their performances.
Back to back draws with Torino and Atalanta allowed Napoli to close the gap to just five points, meaning Roma will be in all sorts of problems if they lose to Inter Milan.
And while the Giallorossi are unbeaten in last 13 away fixtures, they have only won two of last seven league matches on the road.
Roma have been priced at 3.30 (23/10) to defeat Inter and edge closer to a top 3 finish, but they will have to work hard for a win at Giuseppe Meazza.
Davide Astori misses out through suspension, while Miralem Pjanic, Douglas Maicon, Leandro Castan and Kevin Strootman are unavailable as well.
Probable starting line-up (4-3-3): De Sanctis – Florenzi, Yanga Mbiwa, Manolas, Holebas – Keita, De Rossi, Nainggolan – Gervinho, Totti, Ljajic.