Neighbours Villarreal and Valencia will contest Derby de la Comunitat at El Madrigal, with both sides hoping to build on the impressive start to the season.
The Yellow Submarine continued where they left off last season, putting in some good performances in both La Liga and Europa League.
Villarreal eased off to the EL group stages before taking seven points from first three games to all but secure a place in the knockout phase.
Meanwhile, Marcelino Garcia Toral’s charges experienced some problems in the opening exchanges of the league campaign, but have shown a great deal of improvement of late.
Villarreal impressed to record back to back wins over Celta Vigo and Almeria, and they came really close to shocking red-hot Sevilla on the road.
The Yellow Submarine went into the final stages of the game with a one-goal lead, but then conceded two very late goals to lose the match 2-1.
And despite missing a chance to record the fifth straight win in all competitions, Villarreal have been made 2.15 (23/20) favourites to defeat Valencia on Sunday.
With Matteo Musacchio injured and Victor Ruiz highly unlikely to feature, coach Marcelino Garcia Toral was delighted to welcome back Gabriel and Dorado, who should form the centre-back pairing. Antonio Rukavina also returns.
Probable starting line-up (4-4-2): Asenjo – Mario, Gabriel, Dorado, Jaume Costa – Cheryshev, Trigueros, Bruno, Cani – Uche, G. Dos Santos.
Valencia have enjoyed one of the best starts in recent years and they currently sit mere two points behind La Liga leaders Barcelona.
A top 4 finish in the league is obviously the priority this term, and los Che look more than capable of living up to the expectations, even if that is not going to be an easy task.
Valencia have showed incredibly consistency this season, with 3-0 loss at Deportivo La Coruna probably the only under-par result of the campaign, and they go into the local derby in great spirits.
Los Che recovered well from the said loss to defeat Elche at home and can now be backed at 3.60 (13/5) to defeat Villarreal at El Madrigal.
The club have suffered a major blow as key midfielder Daniel Parejo picked up a hamstring injury, with Brazilian Filipe Augusto tipped to replace him.
Defender Lucas Orban is unlikely to feature as he battles a toe injury, while Carles Gil and Sofiane Feghouli should also miss out.
Probable starting line-up (4-3-3): Alves – Barragan, Mustafi, Otamendi, Gaya – Gomes, Fuego, Augusto – Rodrigo, Alcacer, Piatti.