AC Milan returned to winning ways as they defeated Sampdoria on the road, but the triumph will mean little if they fail to beat Lazio in midweek.
The Biancocelesti recorded a comfortable victory over Pescara last time out, and are now looking to extend the good run on the travels.
AC Milan have had a slow start to the season, recording a fortunate victory over Torino before losing their next two league fixtures, but they are now finally back in business.
The Rossoneri recorded a hard-fought triumph at Marassi thanks to a late goal by Carlos Bacca, who had to start from the bench after an altercation with coach Vincenzo Montella.
That did not prove such a bad decision as his replacement Gianluca Lapadula played really well for over an hour, before the Colombian came on to score the winning goal.
Bacca, who had previously complained about the lack of service, is expected to return to the side, with Suso and Niang likely to keep their places on the wings.
Juraj Kucka is back in contention, but he is not certain to start, with Keisuke Honda also waiting for his chance on the bench.
Meanwhile, Matias Fernandez, Luca Antonelli, Andrea Bertolacci, Mattia De Sciglio and Cristian Zapata remain on the sidelines.
Probable starting line-up (4-3-3): Donnarumma – Abate, Paletta, Romagnoli, Calabria – Sosa, Montolivo, Bonaventura – Suso, Bacca, Niang.
Similar to AC Milan, SS Lazio have struggled to return to old glory days in recent years, but the team enjoyed a positive start to the new campaign.
Considering that they also faced champions Juventus, the return of 7 points from 4 league fixtures is not bad at all, and it saw the Biancocelesti climb to fourth in the standings.
Following the 1-1 draw with Chievo, Lazio worked hard to break defence-minded Pescara, but eventually scored three second-half goals to the delight of home fans. The Biancocelesti can now be backed at 3.70 (27/10) to claim maximum points and extend their unbeaten run on the road to four games.
Key midfielder Lucas Biglia remains doubtful through a muscle injury, while Balde Diao Keita could replace Filip Djordjevic in the starting line-up.
Probable starting line-up (3-5-2): Marchetti – Bastos, De Vrij, Radu – Anderson, Parolo, Cataldi, Milinkovic-Savic, Lulic – Immobile, Keita.