High-flying Genoa need to improve their home form if they want to stop the Serie A leaders in the tracks having won just one of four matches at Stadio Luigi Ferraris.
Meanwhile, the Bianconeri extended their lead at the top by defeating Palermo, but they may have bigger fish to fry on Wednesday evening.
Having experienced all sorts of problems over the last few seasons, Genoa finally enjoyed a bright start to the season, albeit mostly thanks to impressive showings on the road.
The Rossoblu are still unbeaten on the travels, having shared spoils with Fiorentina and Hellas Verona before defeating Parma and Chievo.
This has seen them climb to ninth in the overall standings, although the poor home form should be a major cause for concern.
Genoa did well to defeat very good Lazio at Stadio Luigi Ferraris, but could only muster a 1-1 draw with Empoli while losing to Napoli and Sampdoria.
With that in mind, the Rossoblu will have to show a major improvement if they are to get anything from the Juventus clash, where they are 2.63 (13/8) not to lose.
Important midfielder Stefano Sturaro should return to the side, but Tomas Rincon and Ioannis Fetfatzidis remain on the sidelines.
Probable starting line-up (3-4-3): Perin – Roncaglia, Burdisso, De Maio – Edenilson, Bertolacci, Sturaro, Antonelli – Perotti, Matri, Kucka.
Juventus go into this game three points clear at the Serie A summit, but it looks as though Roma will push them all the way this term.
While impressing on domestic stage, the Bianconeri are again struggling in Europe and they find themselves in a very difficult situation following defeats to Atletico and Olympiakos.
Juventus recovered well from the unfortunate loss in Athens to defeat Palermo at home at the weekend, with Fernando Llorente finally scoring his first goal of the season.
And with the Old Lady winning three straight away matches before sharing spoils with Sassuolo, they can be backed at 1.53 (8/15) to defeat Genoa as well.
Carlos Tevez has finally received a long-awaited call up to the national team and he is 2.10 (11/10) to celebrate it with a goal at Stadio Luigi Ferraris.
Roberto Pereyra is doubtful with a hip problem, while Patrice Evra has joined Andrea Barzagli, Martin Caceres and Simone Pepe in the infirmary.
Probable starting line-up (3-5-2): Buffon – Ogbonna, Bonucci, Chiellini – Lichtsteiner, Pogba, Pirlo, Vidal, Asamoah – Tevez, Morata.