The old rivals square off at Celtic Park following some very good results at the weekend and we can safely say this will be anything but a friendly game.
Improved Scotland will be out to try and prove they are ready to leave the shadow of their more illustrious opposition, while England obviously aim to show they remain the number one side in the UK.
For the first time after quite a while, Scotland have a realistic chance of reaching a tournament finals, and that speaks volumes about the efforts of Gordon Strachan and his charges.
The Scots were pretty unfortunate to be placed in the same group as Germany, Poland and Ireland, but they have so far done brilliantly to stay in contention.
Scotland enjoyed an invaluable triumph over Republic of Ireland at the weekend and no doubt they will be buoyed by that result.
And with England not exactly performing to their best at the moment, there may be value in odds of 3.75 (11/4) offered on home win.
Gordon Strachan is expected to make changes to his starting line-up, with Celtic keeper Craig Gordon tipped to start in front of the home fans.
Steven Fletcher is likely to miss out with an ankle problem, whilst Darren Fletcher faces a fitness test after missing training on Monday.
Probable starting line-up (4-2-3-1): Gordon – Whittaker, R. Martin, Hanley, Robertson – Brown, Bannan – Maloney, Dorrans, Anya – Naismith.
England kept the 100 per cent record intact as they came from a goal behind to defeat Slovenia 3-1, but they cannot afford to relax just yet.
Even of Roy Hodgson plans to rest some of his star players against Scotland, the Three Lions cannot afford to take the game lightly, as this match is more than just about the bragging rights.
The fact of the matter is that England had been placed in one of the easiest Euro 2016 qualifying groups, and their latest performances were not exactly up to the highest standard.
The Three Lions will want to finally put in a good showing against a top side and they are 2.25 (5/4) to win in Glasgow.
Saido Berahino and Ross Barkley are expected to start, while Phil Jagielka is available despite suffering an injury against Slovenia.
Joe Hart was allowed to return to his club, meaning that former Celtic shot-stopper Fraser Forster will start in goal.
Probable starting line-up (4-4-2): Forster – Chambers, Smalling, Cahill, Gibbs – Wilshere, Chamberlain, Milner, Barkley – Rooney, Berahino.