Hosts Chile are eager to finally end the barren run and lift the Copa America trophy at the fifth attempt, having lost previous four finals.
Argentina, on the other hand, are desperate to end a 22-year wait for a major trophy, with La Albiceleste buoyed by the 6-1 hammering of Paraguay.
Chile headed to the 2015 Copa America finals with a clear goal of winning the elusive trophy, and while they experienced some problems on the road, Jorge Sampaoli’s charges have got to be congratulated for reaching the final.
La Roja eased off to the first position in their group, before recording hard-fought wins over Uruguay and Peru in the knockout stages.
With Alexis Sanchez struggling for form after a long season, Eduardo Vargas proved an unlikely hero, scoring both goals to help the team defeat La Blanquirroja in the semis.
The two players will be hoping to cause Argentina defenders plenty of problems as well, with Chile priced at 2.50 (3/2) to lift the trophy.
Jorge Samapoli is expected to shake things up at the back, with Francisco Silva coming in for Jose Rojas and Jean Beausejour set to start on the left.
Holding midfielder Marcelo Diaz will have a very important job as he will also act as a sweeper at times to help Chile combat the star-studded Argentina side.
Probable starting line-up (4-3-1-2): Bravo – Isla, Silva, Medel, Beausejour – Vidal, Diaz, Aranguiz – Valdivia – Sanchez, Vargas.
Argentina have endured some tough times of late despite having superstar Lionel Messi in their ranks, with La Albiceleste last winning a major trophy back in 1993.
The South America’s giants showed some improvement to reach the 2014 World Cup final in Brazil, but they were somewhat unfortunate to lose to Germany.
And while Argentina did not really impress at the 2015 Copa America, they recorded several hard-fought wins to enter the final stages of the tournament.
La Albiceleste finally turned on the style in the semi-final, hammering Paraguay 6-1, with Leo Messi playing a key role in almost each of the six goals.
Argentina have, therefore, been made 1.57 (4/7) favourites to lift the coveted trophy in Santiago de Chile, but they will have to work hard to beat hard-working hosts.
Gerardo Martino has no fresh injury worries at the moment, but he will have Ezequiel Garay back to the starting line-up.
Probable starting line-up (4-3-3): Romero – Zabaleta, Garay, Otamendi, Rojo – Biglia, Mascherano, Pastore – Messi, Aguero, Di Maria.