Jose Mourinho will be looking to mastermind Tottenham Hotspur’s route into the last-16 of the FA Cup as they face Southampton in a Fourth Round replay on Wednesday evening.

The two teams came together originally a little over a week ago at St Mary’s and battled to a 1-1 draw. Heung-Min Son had given Spurs the lead mid-way through the second-half, before Sofiane Boufal equalised late on for Ralph Hassenhuttl’s men. This time, there has to be a winner in North London. Tottenham can be backed at a price of 1/3 with Paddy Power to qualify for the Fifth Round of the competition, whilst the Saints are at 9/4 to progress to that stage of the competition for just the second time in the last six seasons.

One aspect that will make the Saints’ task for the match even more difficult is their form when travelling to North London. Since gaining promotion back to the Premier League in 2012, Southampton have only beaten Tottenham once away from home and even that solitary victory came back in May 2016. In fact, Tottenham have won each of the last three matches between the two sides on home soil. This time, Spurs sit at 7/10 with William Hill to win the match within 90 minutes, whilst the Saints are available at 4/1 to pick up a surprise win. Meanwhile, the game to finish level after regulation time between the two teams once again is at 11/4.

One thing that could potentially be predicted between the two sides at the Tottenham Hotspur Stadium are goals. In Premier League action, the two sides only have nine clean sheets between them this season, with no side having fewer than Spurs. As a matter of fact, they have conceded 78 goals between them. Both teams to score this time is at 4/5.

Spurs have potentially added another key name to their injury list, with Dele Alli having suffered an ankle knock and having to be replaced against Manchester City on Sunday. He could potentially be ruled out alongside Harry Kane, Moussa Sissoko and Ben Davies. Elsewhere, Yann Valery could bring some good news to Saints with his return from injury but Stuart Armstrong remains missing until at least mid-February.

One man that will be hoping to take to the field again though is Son, who has had a hand in a third of Tottenham’s goals this season. He is at 7/2 with Betfair to score the opening goal of the game on Wednesday evening. Meanwhile, Southampton’s key man, Danny Ings can be backed at 4/1.