Scotland boss Gordon Strachan will have his work cut out for him in the build up to the 2018 World Cup qualifier against England as no fewer than five players were forced to withdraw.
The Tartan Army revived their qualifying hopes with a narrow win over Slovenia, but they now also need to try and beat their bitter rivals at Hampden Park.
That was never going to be an easy task, and it has now just become a lot more difficult due to numerous injury worries.
Namely, Steven Fletcher, Kenny McLean, John McGinn, Jamie Murphy and Jack Hamilton have all been dropped from the squad.
Full-back Kieran Tierney picked up a facial injury in the Scottish Cup final, but he remains in the squad and should be fit to play.
Scotland play host to England at Hampden Park on 10th June and they are 9/2 chance to defeat the Three Lions and edge closer to a play-off berth.