The hosts have just one league win to their name this season, and go in to the game on the back of a 1-0 defeat to fellow strugglers Aston Villa on Tuesday evening.
The result left Brian McDermott’s men on just nine points, though they do have a game in hand on almost every team above them.
Jimmy Kebe could return for the Royals after recovering from a groin injury, though they remain without Chris Gunter, Alex McCarthy, Danny Guthrie and Jem Karacan.
Unsurprisingly, Reading are outsiders for this game, and are widely available at 8.0 (7/1) whilst the visitors are odds on favourites for the victory, with Bet Victor offering the best price of 1.45 (9/20). The draw is priced at 4.8 (19/5) with the same firm.
Manchester United maintained their position at the top of the division with a 1-0 victory over West Ham United on Wednesday, with top scorer Robin Van Persie grabbing the only goal of the game.
The Dutch striker is now on 12 for the season, and is 4.33 (10/3) with Bet 365 to add to that tally by opening the scoring on Saturday evening.
Antonio Valencia could be involved after missing the last three games through injury, though Nemanja Vidic, Shinji Kagawa and Nani are all out.
Manchester United came from behind to win yet again last weekend against Queens Park Rangers, so you may be tempted to take advantage of the 3.6 (13/5) on offer from Bet 365 for Reading to score the first goal of the game.
It is almost five years since United ran out 2-0 winners at the Madejski Stadium when the sides last met. Wayne Rooney opened the scoring that day, and the England striker is well overdue a goal having not hit the net in six league games.
Bet Victor offer the best price of 2.1 (11/10) that Rooney will hit the net at any time, whilst you can back him to score two or more goals at the rather generous price of 7.5 (13/2) offered by Coral.