Arsenal hope to make amends for their Premier League setbacks and finish top of their Champions League group with three points from Athens.
However, the Gunners also need rivals Schalke not to win at Montpellier if they want an easier draw in the Last 16 stage.
If Arsenal win their Champions League group, Ladbrokes will pay out at double the odds on winning first goalscorer bets for their match against Olympiacos.