Two late goals scored by Cristiano Ronaldo in the first leg have made all the difference and now Atletico Madrid have a mountain to climb.
Real Madrid, on the other hand, just need to finish the job at Vicente Calderon and secure third final appearance in four years.
These past few years have both been successful and difficult at times, as two second-place finishes in the Champions League are definite bittersweet.
What is more, Atletico Madrid look set to be stopped on the way to the UCL trophy by Real Madrid third time in last four years, which is definitely a lot to bear.
Los Colchoneros have no choice but to try and at least win the return leg, although they will attempt to score an early goal and maybe make the tie interesting again.
Atletico Madrid returned to winning ways at the weekend as the narrow triumph over Eibar all but secured a third-place finish, but they will obviously have bigger fish to fry on Wednesday.
Diego Simeone welcomes back stopper Stefan Savic from domestic suspension, whereas Jose Maria Gimenez and Juanfran Torres have recovered from injury.
Probable starting line-up (4-4-2): Oblak – Gimenez, Savic, Godin, Filipe Luis – Koke, Gabi, Saul, Carrasco – Griezmann, Gameiro.
Real Madrid have flourished under Zinedine Zidane and this is turning out to be a very successful season for Europe’s most decorated club.
Even though Barcelona currently lead the chase in Spanish La Liga, los Blancos are widely expected to lift the title as they also have a game in hand.
On the other hand, Real Madrid are on the road to become the first ever side to win back to back UCL titles and there are just two more obstacle left to negotiate.
The first is all but crossed after the 3-0 victory in the first leg and it would take a genuine miracle for los Blancos to miss out on the Champions League final.
Zinedine Zidane had the courtesy of resting no fewer than nine starters in the 4-0 hammering of Granada, with key men now set to return.
The Frenchman will be without Gareth Bale and Daniel Carvajal, with Danilo expected to start on the right hand side.
Probable starting line-up (4-3-1-2): Navas – Danilo, Varane, Ramos, Marcelo – Modric, Casemiro, Kroos – Isco – Benzema, Ronaldo.