Napoli climbed to third place despite being denied a victory at Roma, but with three other teams also sitting on 55 points, the Azzurri have got to try and win this game.
Palermo slipped into the danger zone following the six-match winless run and they, too, will have something to play for at San Paolo.
Napoli have had their share of disappointments this term, but they can still turn this season into a success, provided they can clinch Champions League qualification or at least win the Coppa Italia final against Juventus.
The team have been showing a lot of improvement of late and they were close to recording their third straight victory, only to be denied three points by Roma’s Fabio Simplicio.
Walter Mazzarri’s side now return to home comforts and they are odds on favourites to beat out-of-form Palermo, with Stan James paying 1.44 (4/9) on home win.
Even if both Ezequiel Lavezzi and Goran Pandev have returned into action, Mazzarri appear to be set to leave both players on the bench as he opts for a 3-5-1-1 formation. Marco Donadel, Hugo Campagnaro and Antonio Rosati remain on the sidelines.
Probable starting line-up (3-5-1-1): De Sanctis – Fernandez, Cannavaro, Aronica – Maggio, Inler, Gargano, Dzemaili, Zuniga – Hamsik – Cavani.
Palermo continue to disappoint their fans and if this season lasted just few weeks longer, the Rossoblu would probably be in danger of being relegated to Serie B.
While Palermo were always struggling on the travels, the team were a real force to be reckoned with at their Renzo Barbera, but just 2 points from last 6 home outings suggest that is no longer the case.
Oddly enough, the Rossoblu have been showing some improvement on the travels, having picked up 6 points from last 4 away games, meaning they have some reason for optimism before the trip to San Paolo.
Giulio Migliaccio and Eros Pisano are back in contention, but Federico Balzaretti and Francesco Della Rocca are out injured.
Probable starting line-up (3-5-2): Viviano – Munoz, Silvestre, Mantovani – Bertolo, Migliaccio, Donati, Barreto, Ilicic – Hernandez, Miccoli.