Following a dismal start to the 2014 World Cup qualifying campaign, this might feel as a must-win game for both Wales and Scotland.
With sides like Croatia, Belgium and Serbia also in their group, the Home Nations could need a real miracle to make it to Brazil.
Despite the dismal results under Chris Coleman, the players insist they are still behind their manager, but that is likely to change if Wales don’t start winning any time soon.
The Dragons have lost all five games under the former Fulham boss, scoring just one goal in the process, so no wonder their chances of reaching the tournament finals look bleak at the moment.
Wales can be expected to show some improvement after the 6-1 hammering in Serbia, but odds of 2.88 (17/9) offered at 888sport on home win do not look too tempting.
Gareth Bale and Adam Matthews are both expected to start despite carrying knocks, but David Edwards, Jack Collison, James Bellamy, Neil Taylor and James Collins are definitely out.
Keepers Wayne Hennessey and Boaz Myhill also miss out, meaning that Aberdeen’s James Brown is likely to start between the sticks.
Probable starting line-up (4-4-2): Brown – Gunter, Williams, Blake, Matthews – Ramsey, Allen, Ledley, Bale – Morison, Church.
Despite Craig Levein’s assurances that his side can mix it up with the best of them, Scotland had a pretty disappointing start to the 2014 World Cup qualifiers.
While the Tartan Army showed some promise in the goalless draw against Serbia at Hampden Park, they were completely outplayed by FYR Macedonia at the same ground and were fortunate not to lose the game.
Realizing that his job was on the line, Craig Levein was forced to eat his words and bring Steven Fletcher back to the reckoning, with the Sunderland striker, who bagged 5 goals in as many games for his new club, 3.25 (9/4) with Stan James to score in Cardiff.
Forwards Jordan Rhodes and Robert Snodgrass have both withdrawn from the squad, while Steven Naismith misses out through suspension.
The good news is Celtic stars Scott Brown and Charlie Mulgrew are expected to recover just in time to start the Wales game.
Probable starting line-up (4-1-4-1): McGregor – Hutton, Webster, Berra, Mulgrew – Caldwell – Morrison, Brown, Adam, Maloney – Fletcher.