The two sides met at the Euro 2012, with England beating the tournament co-hosts 1-0, and the Three Lions are certainly hoping for another victory over the same opponents.
Ukraine, on the other hand, hope to start their 2014 World Cup qualifying campaign on a high, and for that they will need to bring at least one point from Wembley.
For the first time after quite a while, England kicked-off a qualifying campaign with a resounding victory, and even if it was weak Moldova on the other side, the whole nation is hoping this will be a sign of things to come.
The Three Lions have certainly found some consistency under Roy Hodgson, having won five and drawn two games under his command, so no wonder the whole country is optimistic about team’s chances to reaching the 2014 World Cup in Brazil.
The absence of a proven goalscorer didn’t prove to be a problem in Moldova, but we have yet to see who the new look attack will fare against more serious opponents.
However, even if the hosts go into this game high on confidence, odds of 1.40 (2/5) offered at Stan James on home win don’t look tempting to me.
John Terry has been added to the list of casualties that already contained the likes of Wayne Rooney, Andy Carroll, Ashley Cole, Gareth Barry and Scott Parker, with Gary Cahill or Phil Jagielka expected to step in.
Update: Raheem Sterling, Adam Lallana and Jake Livermore have been drafted into the squad after Theo Walcott withdrew because of injury.
Probable starting line-up (4-2-3-1): Hart – Johnson, Cahill, Lescott, Baines – Lampard, Gerrard – Milner, Cleverley, Oxlade-Chamberlain – Defoe.
Ukraine missed the opportunity to reach the Euro 2012 final stages despite playing on home soil, even if the team showed plenty of potential in all three games.
Oleg Blokhin’s side have since been placed into a very difficult group for the 2014 World Cup qualifiers, with Poland, Montenegro and England all going into the qualifiers with the same objective.
The experienced coach enters the new qualifying campaign with virtually the same squad he used at the Euro 2012 finals, and while he can count on several excellent attacking midfielders, the boss is hardly spoilt for choices when it comes to centre forwards.
Having failed to score a single goal in last three games, Ukraine are 1.83 (5/6) with Sportingbet to continue the dismal run.
Since Andriy Shevchenko and Andriy Voronin have both retired from international football, Marko Devic is expected to lead the attack in England.
Probable starting line-up (4-2-3-1): Pyatov – Husyev, Mykhalyk, Khacheridi, Selin – Tymoshchuk, Rotan -Yarmolenko, Garmash, Konoplyanka – Devic.