The Premier League giants are set to meet again just three days after Manchester United recorded a controversial victory at Stamford Bridge.
We may not see so many star players on the pitch this time, but the motivation and passion should remain the same.
Chelsea go into this game eager to get revenge on their rivals for the unjust defeat on Sunday, while looking to avoid the third successive defeat.
The Blues can take a lot of heart from the weekend’s performance having done well to come back into the game from two goals down, while they have every right to feel aggrieved with Mark Clattenburg and his assistants for sending off Fernando Torres and allowing United to score the third goal from an offside position.
As much as Roberto Di Matteo wants to win this Capitol One Cup match, he is aware that his star players need some rest and the Italian is expected to make wholesale changes to the side.
However, with his United counterpart set to do the same, Chelsea still look a good bet at odds of 2.38 (11/8) offered at Paddy Power.
Branislav Ivanovic, Fernando Torres and John Terry are all banned, while Frank Lampard continues to miss out.
Probable starting line-up (4-2-3-1): Turnbull – Azpilicueta, Luiz, Cahill, Bertrand – Romeu, Mikel – Moses, Marin, Sturridge – Piazon.
Manchester United continue to record impressive results even though everybody can see there is still a lot of room for improvement.
The reality is, however, that United have won 12 of last 13 games in all competitions, despite the serious selection worries Sir Alex Ferguson has had since the season started.
The Red Devils did need a lot of help from the ref to win at Stamford Bridge, but that is unlikely to prevent them from feeling optimistic ahead of another trip to London.
With Sir Alex Ferguson set to rest all his starters, odds of 3.10 (21/10) offered at 888sport on away win do not look too tempting.
Nemanja Vidic, Chris Smalling, Phil Jones and Shinji Kagawa are all unavailable, but Anderson, Darren Fletcher and Danny Welbeck should start.
Probable starting line-up (4-2-3-1): Lindegaard – Vermijl, Wooton, Keane, Buttner – Fletcher, Anderson – Nani, Giggs, Welbeck – Chicharito.