Neither side have taken this competition too seriously in the past, but that looks set to change with both managers set to field very strong line-ups.
With that in mind, there is every chance we will see a fiery encounter when Tottenham take on Lazio at White Hart Lane.
The Luka Modric transfer saga seriously disrupted Spurs’ preparations for the new season and only after the Croatian finally completed the move to Real Madrid were the club officials able to seriously delve into the transfer market.
New signing Moussa Dembele, Jan Vertonghen, Clint Dempsey and Gylfi Sigurdsson have all shown a lot of promise, but it was one of the old guard who stole the show.
With three goals in his first four league games, Jermain Defoe proved he can successfully operate as a lone striker, with the England international now 2.62 (13/8) with 888sport to score against Lazio as well.
Having finally recorded their first win of the season, a 3-1 victory over Reading, Spurs will fancy their chances in this match, so you should know home win pays 1.87 (20/23) at BetVictor.
Andre Villas-Boas was adamant his side would take the Lazio game very seriously, but the Portuguese manager is, nonetheless, expected to make some changes to the starting line-up.
Benoit Assou-Ekotto remains sidelined, but Emmanuel Adebayor, Clint Dempsey, Hugo Lloris and Michael Dawson are pushing for starting places.
Probable starting line-up (4-2-3-1): Lloris – Walker, Dawson, Caulker, Naughton – Huddlestone, Sandro – Lennon, Dempsey, Bale – Adebayor.
Despite finishing the Serie A campaign in 4th place, in front of Napoli, Inter and Roma, Lazio boss Edy Reja was sacked from the post at the end of the season, with virtually unknown coach Vladimir Petkovic brought to replace him.
With no major signings in the transfer window, the Biancocelesti fans were skeptic before the start of the new season, but their beloved team have done brilliantly to dispel all the doubts.
The Sky Blues not only recorded a double win over Slovenian side Mura to reach the Europa League group stages, but they won all three Serie A games, despite being handed some tricky ties.
Considering Lazio arrive to London on the back of five straight victories, odds of 4.50 (7/2) offered by Ladbrokes on away win could be worth a shot.
Vladimir Petkovic is expected to take the competition much more seriously than his predecessors, with the Bosnian set to field his strongest line-up.
The only change to the team that recorded a 3-1 win over Chievo will see Lionel Scaloni come in for Abdoulay Konko.
Probable starting line-up (4-1-4-1): Marchetti – Scaloni, Biava, Andre Dias, Cavanda – Ledesma – Candreva, Gonzalez, Hernanes, Mauri – Klose.