AS Roma face an uphill task after the 4-2 loss in the first leg at Parc OL, but the Giallorossi definitely have the potential to overturn the two-goal deficit.
Having produced yet another memorable performance in Europe, Lyon are in good position to reach the quarter-finals and continue marching towards the Europa League trophy.
AS Roma have been putting in some very good displays from the start of the season, but the Giallorossi now need to enjoy a strong finish or else this could turn into a disappointing campaign.
Even if they missed the opportunity to close the gap behind leaders Juventus, Luciano Spalletti’s side sit pretty in second place, some eight points adrift of Serie A holders.
The 3-0 away win over Palermo acted as an important confidence boost after the run of three successive defeats in all fronts, with former Lyon star Clement Grenier impressing on his first start for the club.
A much changed side that face the Rosanero is enough to suggest that Luciano Spalletti is taking the return leg against les Gones very seriously and AS Roma are now 3.25 (9/4) shot to qualify for the Round of 8.
Full-back Bruno Peres may not be able to feature having picked up a thigh strain at the weekend, meaning that the boss may revert to a four-man back line.
Probable starting line-up (4-2-3-1): Szczesny – Rudiger, Manolas, Fazio, Juan Jesus – Strootman, De Rossi – Perotti, Nainggolan, Salah – Dzeko.
Even if Lyon have been unable to mount a serious title challenge in Ligue 1 over the past few years, their European performances have remained pretty impressive.
Les Gones have got plenty of European experience and new players coming through the ranks seem to quickly adapt to playing European football.
Lyon were quite unfortunate not to reach the Champions League Round of 16 having completely outclassed very good Sevilla side in the final group game, but they have since continued with excellent performances in the Europa League.
Les Gones were handed a very tough draw as they were pitted against high-flying AS Roma after the 11-2 aggregate win over AZ Alkmaar, but they seemed unmoved by the strength of the opposition.
Lyon came from a goal down to record a 4-2 triumph in the first leg and they now stand a very good chance of reaching the next stage.
There have been more good news for coach Bruno Genesio as he was able to take a fully fit squad to Stadio Olimpico, although Memphis Depay is ineligible.
Probable starting line-up (4-2-3-1): Lopes – Rafael, Mammana, Diakhaby, Morel – Tousart, Gonalons – Ghezzal, Tolisso, Valbuena – Lacazette.