PSV Eindhoven have no choice but to try and beat under-strength Napoli after losing to Dnipro in their opening game, whereas the Azzurri are under no pressure following the 4-0 triumph over AIK.
The Dutch giants missed out on a Champions League berth by a single point and had to settle for a place in Europe League.
With the squad undergoing only minor changes in the summer, PSV eased off to a 14-0 aggregate win over Zeta to reach the group stages, but they could do nothing to avoid a 2-0 defeat to Dnipro at the start of the group phase.
The team have since returned to the right track, scoring 12 goals in 3 domestic victories, and with that in mind, PSV can be backed to score two goals or more at odds of 2.20 (6/5) offered by Stan James.
Going into this game on the back of a 6-0 triumph over VVV Venlo at the weekend, Dick Advocaat’s side are 2.05 (21/20) with Sportingbet to see off Napoli as well.
Tim Matavz could return after missing the weekend’s game with a bout of flu, while Stanislav Manolev is back from a domestic suspension. Jetro Willems, Erik Pieters and Mathias Jorgensen remain sidelined.
Probable starting line-up (4-2-3-1): Tyton – Hutchinson, Derijck, Marcelo, Bouma – Toivonen, Van Bommel, Strootman – Narsingh, Lens, Mertens.
SSC Napoli have progressed a great deal over the last few years and they are on the road to return to old glory days.
Goran Pandev and Lorenzo Insigne have done well to compensate for the departure of Ezequiel Lavezzi, and as a result, the Azzurri enjoyed a brilliant start to the season.
Walter Mazzarri’s side climbed to the top of Serie A standings with 16 points from first 6 games, while they hammered AIK 4-0 in their opening Europa League fixture.
Even if the Italians arrive to Eindhoven without several first team regulars, one should bear in mind away win pays 3.75 (11/4) at BetVictor.
Marek Hamsik is suspended, while Christian Maggio and Alessandro Gamberini miss out through injury. Edinson Cavani, Goran Pandev and Gokhan Inler are among those rested for this clash.
Probable starting line-up (3-5-1-1): Rosati – Fernandez, Cannavaro, Aronica – Mesto, Behrami, Donadel, Dzemaili, Dossena – Insigne – Vargas.