The hosts go in to the game in ninth place following Saturday’s results and will hope for a positive result after losing each of their last three matches.
Their latest defeat came at the hands of Everton, who came from two goals down to take all three points on Merseyside a fortnight ago.
Marco Silva, who has been linked with the vacant managers post at Goodison Park will be booted by the return of goalkeeper Heurelho Gomes, who went off injured against the Toffees while Christian Kabasele, Sebastian Prodl and Roberto Pereyra are also avaiable.
However, Younes Kaboul remains sidelined while captain Troy Deeney is suspended.
Andre Gray can be backed at 6.5 (11/2) to get the first goal of the game with Sporting Bet with Richarlson available at the same price with Bet 365.
New Hammers manager David Moyes sees his team one point from safety ahead of his first match in charge and knows a win here would see him climb out of the bottom three and above both West Bromwich Albion and his former side Everton.
Javier Hernandez will miss out with a hamstring injury though Michail Antonio could be available after recovering from a similar issue.
Pablo Zabaletta is set to return after serving a suspension while Winston Reid may feature despite only returning from international duty with New Zealand on Friday.
Andy Carroll is 7.5 (13/2) to open the scoring with a variety firms, ahead of 10.0 (9/1) chance Andre Ayew.
Last season’s corresponding fixture ended 1-1, five months after the Hornets ran out 4-2 winners at the London Stadium.
In fact, both teams have scored in four out of the last five meetings between the sides and you can back that to be the case this time around at 1.73 (8/11) with a number of bookmakers.