The amazing comeback from the home side in the same fixture last season helped Manchester City win their first league title after 44 years, but it almost saw QPR get relegated from the Premiership.
This is a must-win game for the Citizens following the disappointing showing at Anfield, whereas their opponents will have something to prove as well, having taken just one point from first two games.
The transfer deadline day is in front of us and City have yet to bring a high-profile player this summer, with Jack Rodwell and Scott Sinclair not exactly the players the fans expected to see at Etihad.
Nevertheless, with most of the title wining squad still together, Roberto Mancini still has plenty of quality players at his disposal and the Citizens can be trusted to hit the ground running any time now.
Despite winning two of their first three games of the season, City are clearly far from the desired form, as witnessed by the poor performance in the 2-2 draw at Anfield.
A comfortable home win could be just the boost the team need to return to the right track, so bear in mind they are 1.62 (8/13) with Stan James to win by two goals or more.
Sergio Aguero, Micah Richards and Gareth Barry remain sidelined, but Gael Clichy and Joleon Lescott are expected to return.
Probable starting line-up (4-2-3-1): Hart – Zabaleta, Kompany, Lescott, Clichy – Milner, Y. Toure – Nasri, Tevez, Silva – Balotelli.
Unlike their next opponents, QPR have been very active in the summer transfer window and they are on the road to create a very good team for Premier League standards.
The Rs have added Julio Cesar, Stephane Mbia and Esteban Granero to what already looks like a star-studded line-up, although only former Inter keeper is expected to start against City.
Mark Hughes, nevertheless, now has a plethora of talented players at his disposal and the odds are heavy defeats like that at the start of the season will soon become a thing of the past.
Rangers were very fortunate to escape Carrow Road with one point last weekend, having been completely outplayed by Norwich, but everybody at the club is hoping the arrival of new players will spur on the team to a great performance at Etihad.
Just so you know, Queens Park Rangers are 7.70 (67/10) with Betfair to pick up one point from this game.
New signings Esteban Granero and Stephane Mbia are likely to be left on the bench, but Julio Cesar should start in goal.
Probable starting line-up (4-4-2): Cesar – Bosingwa, Nelsen, Ferdinand, Fabio – Taarabt, Diakite, Park, Hoilett – Zamora, Cisse.