The majority of discussion around the match has been, quite rightly, about events off the field though come 13:30 GMT, all focus will be on a battle which has provided no shortage of drama over the years.
There is quite simply no bigger match in the English game, and fewer are more difficult to call; something which is best represented in the 3 way market.
Many bookmakers have exactly the same price on offer for the home and away victory, with William Hill’s offer of 2.8 (9/5) being the best price available for the visitors. You can however get a slightly higher price of 2.88 (15/8) from Ladbrokes for the home side to come out on top. The draw is available at 3.3 (23/10).
The corresponding fixture finished all square last season; Javier Hernandez cancelling out Steven Gerrard’s opener. The England captain, who already has seven goals against United in his career, is 11.0 (10/1) with most firms to open the scoring once again.
As well as Gerrard, Liverpool are expected to recall several other first team players rested in Thursday’s Europa League victory over Young Boys, with Luis Suarez once again set to lead the line. The Uruguayan is 8.5 (15/2) with Stan James to get the first goal of the game.
Manchester United are also set to ring the changes, as they go in search for a first league win at Anfield for five years.
Striker Robin Van Persie, who began on the bench in United’s 4-0 win over Wigan last time out in the league is expected to start upfront, and is the 6.0 (5/1) favourite to score first, whilst Paul Scholes, who opened the scoring last weekend, is also worth considering at 19.0 (18/1) with Bet Victor.
Clean sheets are a rarity in this fixture, with only one kept by either side in the last eight league meetings. With this in mind, the offer of 1.73 (8/11) from Bet Victor for both teams to score in the match looks rather generous.