Belgian midfielder Marouane Fellaini is expected to be in contention for the local derby against Manchester City, according to reports in England.
The 30-year-old missed the 2-0 triumph over Swansea City through injury, but he should be fit to take a place on the bench for the Manchester derby.
Sergio Romero and Daley Blind continue to miss out, but Phil Jones and Marcos Rojo will be back in contention, although neither is expected to start.
Talented midfielder Scott McTominay is expected to keep his place despite the fact that both Marouane Fellaini and Ander Herrera are back, with Pogba and Matic the mainstays in Man Utd midfield.
Lone striker Romelu Lukaku should be supported by January recruit Alexis Sanchez and improving Jesse Lingard as Man Utd hope to prevent their local rivals from clinching yet another Premier League trophy.
The Red Devils can be backed at 4.00 (3/1) to emerge victorious, while Man City are priced at 1.91 (10/11) to secure the league trophy with six games to spare.