Wednesday evening’s match at Stamford Bridge sees champions Chelsea take on struggling Swansea City.
Antonio Conte’s men extended their unbeaten league run to five games at the weekend but only managed to draw against Liverpool though a return to winning ways here would move them to within three points of Manchester United, who beat Watford on Tuesday evening.
Anything other than a win for the Blues here could see Arsenal leapfrog them, should they beat Huddersfield Town while Liverpool, who travel to Stoke City, are also on their coattails.
David Luiz has been ruled out with a knee problem and joins Charly Musonda, Michy Batshuayi and Kenedy on the sidelines, with Victor Moses also a doubt while Cesc Fabregas could return after being dropped for the draw at Anfield.
The home win is widely available at 1.2 (1/5) with the visitors as highly priced as the 19.0 (18/1) on offer from a variety of firms. The draw can be backed at 8.0 (7/1) with Bet 365.
Paul Clement’s side ended a run of five straight defeats at the weekend but only managed a goalless draw against Bournemouth, and they go into this game joint bottom of the league after Crystal Palace took a point from their clash with rivals Brighton and Hove Alibon on Tuesday evening.
However an unlikely win here should see them climb out of the relegation zone with the two sides directly above them, Everton and West Ham United facing each other while West Bromwich Albion only managed to draw with Newcastle United yesterday.
Tammy Abraham is unable to face his parent club while Federico Fernandez misses out due to a family bereavement and Kyle Bartley remains out with a knee injury.
Wilfried Bony is 17.0 (16/1) to open the scoring with Bet 365, ahead of <a href="http://www.freebetting.com/bet-365" rel="noopener" target="_blank" rel="nofollow"21.0 (20/1) chance Jordan Ayew.
Last season’s corresponding fixture ended in a 3-1 win for the hosts, while the game at the Liberty Stadium last Septbember finished 2-2.